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Amlodipine lisinopril combination pill (Trial Tralee 2004) and aripiprazole Brilj 2010) did not find evidence of a difference in quality life between statins and placebos. This was in contrast to trials of statin monotherapy, in which statins improved outcomes primary prevention patients (Trial Brilj 2011 ), improved renal function (Trial Brilj 2011 ), alleviated symptoms of rheumatoid arthritis (Trial Brilj 2010 ), and provided an additional dose of β-blocker (Trial Brilj 2011 ). There is limited information on the effect of statins a range other symptoms and medical conditions. The benefits of statins on promethazine over the counter australia pain and symptoms of rheumatoid arthritis were investigated in a large, observational, double-blinded clinical trial of older adults with rheumatoid arthritis. Statins were compared with placebo in adults severe rheumatoid arthritis over 20 weeks of treatment (DORA–treat trial) (Trial DORA–treat 2009). Statins improved QOL (measured by the International Physical Activity Questionnaire) in adults with rheumatoid arthritis the group who had more severe disease, with a reduction in all symptom measures over the study period. In DORA–treat trial, statins showed some benefit Promethazine 25mg $62.94 - $0.7 Per pill over placebo on clinical activity (a measure of physical undertaken in the last week of trial), but this benefit was offset by a reduction in the number of days patients undertook their usual activities (see Table 4 in the Supplementary Appendix). These results are in clear contrast with findings from the Randomised Control Trial for Treatment of High Blood Cholesterol in Ischaemic Heart Disease (DASH) which found no evidence that statins were more effective than a placebo in patients with or without mild–moderate low back pain (Wong and Wang 2001). There is little information on the effect of statins clinical outcomes in patients with other disease, including cardiovascular disease. Some studies have found that people taking statins have significantly less MI than people not taking statins (Chau et al. 2007 , DORA–treat), but the effects on other outcomes are less clear-cut, due to variability in the statin dose studied (Jankovic et al. 2015 ; Børsheim 2003 ). There are no published data on the effects of statins survival, but the results of trials in patients with cancer seem mixed. One trial found that statins were associated with a statistically significant decreased risk of mortality, but the trial was stopped early because of the size and duration reduction in mortality (Baird et al. 2011 ). A can you buy promethazine cough syrup over the counter larger trial that started less than 24 months after the index patient's cancer diagnosis was stopped found that statins did not reduce mortality (Jankovic et al. 2015 ); however, even short-term use of statins is associated with modest health improvements (Wong and Wang 2001). Table 4. Side-effects of statins (see Table 1 <$%INSIDE_LINK_0%$> for main statin effects) In addition to the side-effects identified in studies of statins, statin side-effects are <$%OUTSIDE_LINK_0%$> likely to vary significantly from person person, with some people receiving no side-effect at all. There are a limited number of randomized controlled trials (RCTs) statins in patients with